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The trial has been extended to study the long-term results of weight loss through healthy eating and physical activity programs in older adults with type 2 diabetes. The Longitudinal Assessment of Bariatric Surgery followed more than 2,400 participants with extreme obesity who underwent bariatric surgery at one of the participating centers. In a clinical trial in 258 patients with uncontrolled type 2 diabetes, 2 g/day L-carnitine plus the pharmaceutical ingredient orlistat (360 mg/day) for 1 year significantly increased weight loss compared to orlistat alone [ 86 ].

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